Tuesday, 31 January 2012

Wound Healing

Stages of Wound Healing


Stage 1 (Immediate)
Haemostasis
  • Vasoconstriction
  • Platelet aggregation
  • Thromboplastin makes clot
Stage 2 (immediate to 2-5days)
Inflammatory
  • Vasodilation
  • Phagocytosis
Stage 3 (2days to 3 weeks)
Proliferation
i.   Granulation
  • Fibroblasts lay bed of collagen
  • Fills defect and produces new capillaries
ii.  Contraction
  • Wound edges pull together to reduce defect
iii.  Re-epithelization
  • Crosses moist surface
  • Cell travel about 3 cm from point of origin in all directions
Stage 4 (3weeks to 2 years)
Remodelling
  • New collagen forms which increases tensile strength to wounds
  • Scar tissue is only 80 percent as strong as original tissue

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